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Protein dynamics

Conformational footprints

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The mechanisms by which proteins evolve new functions can be slow and mysterious. Comprehensive structural analysis of enzyme variants reveal how gradual enrichments of pre-existing populations with the right productive dynamics for new functions can accomplish this aim.

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Figure 1: Population shifts of pre-existing protein functional states determine changes in activity.

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Authors and Affiliations

  1. Buyong Ma and Ruth Nussinov are in the Basic Science Program, Leidos Biomedical Research, Inc., and the Cancer and Inflammation Program, National Cancer Institute, Frederick, Maryland, USA.,

    Buyong Ma & Ruth Nussinov

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  1. Buyong Ma
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  2. Ruth Nussinov
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Correspondence to Ruth Nussinov.

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The authors declare no competing financial interests.

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Ma, B., Nussinov, R. Conformational footprints. Nat Chem Biol 12, 890–891 (2016). https://doi.org/10.1038/nchembio.2212

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