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Immunology

JAK3 inhibition—is it sufficient?

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A highly selective JAK3 inhibitor with subnanomolar potency has been used to identify two waves of STAT5 phosphorylation in response to IL-2. This reveals a biphasic role for JAK3 catalytic activity in IL-2-mediated signaling that has therapeutic implications.

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Figure 1: Two waves of STAT5 phosphorylation, the second of which is more sensitive to inhibition by JAK3i.

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Authors and Affiliations

  1. Warren J. Leonard, Suman Mitra and Jian-Xin Lin are in the Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung and Blood Institute, US National Institutes of Health, Bethesda, Maryland, USA.,

    Warren J Leonard, Suman Mitra & Jian-Xin Lin

Authors
  1. Warren J Leonard
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  2. Suman Mitra
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  3. Jian-Xin Lin
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Correspondence to Warren J Leonard.

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Competing interests

W.J.L. and S.M. are inventors related to a patent application on H9-RETR.

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Leonard, W., Mitra, S. & Lin, JX. JAK3 inhibition—is it sufficient?. Nat Chem Biol 12, 308–310 (2016). https://doi.org/10.1038/nchembio.2066

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