Two new studies describe potent and selective inhibitors of CDK8/CDK19. Application of these high-quality probes to several cancer models provides new mechanistic insight and reveals functional dichotomy with respect to Mediator kinases in signal-dependent gene regulation, with important implications for targeted cancer therapy.
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Boyer, T. Less is more (or less). Nat Chem Biol 12, 4–5 (2016). https://doi.org/10.1038/nchembio.1985
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DOI: https://doi.org/10.1038/nchembio.1985
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