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Targeting transcription is no longer a quixotic quest

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Misregulated transcription factors play prominent roles in human disease, but their dynamic protein-protein interaction network has long made the goal of transcription-targeted therapeutics impractical. Recent advances in technologies for modulating protein interaction networks mean that the end of the quest is in sight.

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Figure 1: The chemical space of protein-protein interactions.
Figure 2: Transcription complexes are dynamic in composition and conformation.

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Acknowledgements

The authors thank J. Gestwicki, J. Wells, P. Arora and L. Kiessling for illuminating discussions.

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Authors and Affiliations

  1. Rachel Pricer and Steven Sturlis are at the Life Sciences Institute and the Department of Chemistry, Anna K. Mapp, University of Michigan, Ann Arbor, Michigan, USA.,

    Anna K Mapp, Rachel Pricer & Steven Sturlis

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  1. Anna K Mapp
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  2. Rachel Pricer
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Correspondence to Anna K Mapp.

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Mapp, A., Pricer, R. & Sturlis, S. Targeting transcription is no longer a quixotic quest. Nat Chem Biol 11, 891–894 (2015). https://doi.org/10.1038/nchembio.1962

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