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MicroRNA-lipid one-upmanship

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25-Hydroxycholesterol induces miR-185 to suppress lipid and cholesterol synthesis pathways and inhibit viruses such as hepatitis C virus (HCV), that use host membranes to propagate. HCV counteracts this by suppressing miR-185 expression to drive increased cellular lipid content.

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Figure 1: The miRNA-mediated effects of 25-HC on cellular lipid metabolism and the HCV life cycle.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Patricia A. Thibault is in the Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.,

    Patricia A Thibault

  2. Joyce A. Wilson is in the Department of Microbiology & Immunology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.,

    Joyce A Wilson

Authors
  1. Patricia A Thibault
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  2. Joyce A Wilson
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Correspondence to Joyce A Wilson.

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The authors declare no competing financial interests.

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Thibault, P., Wilson, J. MicroRNA-lipid one-upmanship. Nat Chem Biol 11, 905–906 (2015). https://doi.org/10.1038/nchembio.1953

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