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Stress response

PARP1 911

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Although resveratrol is thought to provide many beneficial health effects, its cellular targets and mechanism of function are still under investigation. A new study found that resveratrol binds to tyrosyl transfer-RNA synthetase, resulting in the activation of the stress response effector PARP1.

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Figure 1: Activation of PARP1 by tyrosyl transfer-RNA synthetase.

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Authors and Affiliations

  1. Florian J. Bock is at the Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.,

    Florian J Bock

  2. Paul Chang is at the Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.,

    Paul Chang

Authors
  1. Florian J Bock
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  2. Paul Chang
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Correspondence to Paul Chang.

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The authors declare no competing financial interests.

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Bock, F., Chang, P. PARP1 911. Nat Chem Biol 11, 179–180 (2015). https://doi.org/10.1038/nchembio.1756

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