The reliable identification of microRNA (miRNA) targets remains an elusive goal. A new technique, using specially modified synthetic miRNAs to directly capture bound RNAs, brings us closer.
This is a preview of subscription content, log in via an institution to check access.
References
Imig, J. et al. Nat. Chem. Biol. 11, 107–114 (2015).
Chi, S.W. et al. Nature 460, 479–486 (2009).
Hafner, M. et al. Cell 141, 129–141 (2010).
Helwak, A. et al. Cell 153, 654–665 (2013).
Friedman, R.C. et al. Genome Res. 19, 92–105 (2009).
Kallen, A.N. et al. Mol. Cell 52, 101–112 (2013).
Salmena, L. et al. Cell 146, 353–358 (2011).
Denzler, R. et al. Mol. Cell 54, 766–776 (2014).
Bosson, A.D. et al. Mol. Cell 56, 347–359 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Grimson, A. Linking microRNAs to their targets. Nat Chem Biol 11, 100–101 (2015). https://doi.org/10.1038/nchembio.1741
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.1741
- Springer Nature America, Inc.
This article is cited by
-
LncRNA-HNF1A-AS1 functions as a competing endogenous RNA to activate PI3K/AKT signalling pathway by sponging miR-30b-3p in gastric cancer
British Journal of Cancer (2020)
-
The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA
Cell Death & Disease (2018)