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Enzyme regulation

A thiol switch opens the gate

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AAA+ proteases are quality control machineries consisting of substrate-binding ATPase modules for protein unfolding and a proteolytic chamber. New research now shows a redox switch in the Escherichia coli Lon protease that controls this process, widening the exit pore and activating proteolysis during transition from anaerobic to aerobic environments.

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Figure 1: Domain structure of E. coli Lon and mechanism of redox control for ATP-dependent proteolysis.

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  1. Haike Antelmann is at the Institute for Microbiology, Ernst-Moritz-Arndt-University of Greifswald, Greifswald, Germany.,

    Haike Antelmann

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  1. Haike Antelmann
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Correspondence to Haike Antelmann.

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Antelmann, H. A thiol switch opens the gate. Nat Chem Biol 11, 4–5 (2015). https://doi.org/10.1038/nchembio.1698

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