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Protein dynamics

Tuning disorder propensity in p53

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An Erratum to this article was published on 20 January 2015

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The dynamic interplay between p53 and Mdm2 triggers cell cycle arrest after DNA damage. A new study reveals that disorder in the transactivation domain of p53 is important for tuning this negative feedback system to ensure normal cellular signaling responses.

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Figure 1: The extent of disorder within p53TAD determines DNA damage-induced cell fate decisions.

Change history

  • 10 December 2014

    In the version of this article initially published, the journal title for reference 4 was omitted. The error has been corrected for the PDF and HTML versions of the article.

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Authors and Affiliations

  1. Richard W. Kriwacki is at the Department of Structural Biology, and the Department of Microbiology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA.,

    Richard W Kriwacki

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  1. Richard W Kriwacki
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Correspondence to Richard W Kriwacki.

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Kriwacki, R. Tuning disorder propensity in p53. Nat Chem Biol 10, 987–988 (2014). https://doi.org/10.1038/nchembio.1692

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