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Protein trafficking

RESETting proteostasis

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A recent study reveals a new cellular pathway that clears the endoplasmic reticulum of misfolded, GPI-anchored proteins at the onset of endoplasmic reticulum (ER) stress. This mechanism, termed rapid ER stress–induced export, represents a nontranscriptional response to mitigate acute ER stress.

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Figure 1: RESET of misfolded GPI-anchored proteins.

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Authors and Affiliations

  1. Julia Noack and Maurizio Molinari are at the Institute for Research in Biomedicine, Bellinzona, Switzerland.,

    Julia Noack

  2. Maurizio Molinari is at the École Polytechnique Fédérale de Lausanne, School of Life Sciences, Lausanne, Switzerland.,

    Maurizio Molinari

Authors
  1. Julia Noack
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  2. Maurizio Molinari
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Correspondence to Maurizio Molinari.

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The authors declare no competing financial interests.

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Noack, J., Molinari, M. RESETting proteostasis. Nat Chem Biol 10, 881–882 (2014). https://doi.org/10.1038/nchembio.1652

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  • DOI: https://doi.org/10.1038/nchembio.1652

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