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Enzymology

A radical finding

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A new family of radical halogenases has been discovered that regio- and stereoselectively chlorinates the unactivated carbon center of indolemonoterpenoid substrates without the prerequisite for the substrate to be bound to a protein carrier.

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Figure 1: Pfam classification of and representative reactions catalyzed by NHI halogenases.

Debbie Maizels/Nature Publishing Group

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Authors and Affiliations

  1. Rebecca J.M. Goss and Sabine Grüschow are at the School of Chemistry, University of St. Andrews, St. Andrews, Fife, UK.,

    Rebecca J M Goss & Sabine Grüschow

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  1. Rebecca J M Goss
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  2. Sabine Grüschow
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Correspondence to Rebecca J M Goss.

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The authors declare no competing financial interests.

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Goss, R., Grüschow, S. A radical finding. Nat Chem Biol 10, 878–879 (2014). https://doi.org/10.1038/nchembio.1649

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