Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory neurotransmission, which is crucial for memory and learning. New cryo-electron microscopy structures of these receptors trapped in distinct functional states provide remarkable insight into conformational changes triggered by agonist binding.
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References
Meyerson, J.R. et al. Nature doi:10.1038/nature13603 (3 August 2014).
Traynelis, S.F. et al. Pharmacol. Rev. 62, 405–496 (2010).
Armstrong, N., Sun, Y., Chen, G.Q. & Gouaux, E. Nature 395, 913–917 (1998).
Jin, R. et al. J. Neurosci. 25, 9027–9036 (2005).
Abele, R., Keinanen, K. & Madden, D.R. J. Biol. Chem. 275, 21355–21363 (2000).
Nakagawa, T., Cheng, Y., Ramm, E., Sheng, M. & Walz, T. Nature 433, 545–549 (2005).
Sobolevsky, A.I., Rosconi, M.P. & Gouaux, E. Nature 462, 745–756 (2009).
Lee, C.H. et al. Nature 511, 191–197 (2014).
Karakas, E. & Furukawa, H. Science 344, 992–997 (2014).
Hansen, K.B. & Traynelis, S.F. J. Neurosci. 31, 3650–3661 (2011).
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Hansen, K., Traynelis, S. Mechanistic twists and turns. Nat Chem Biol 10, 698–699 (2014). https://doi.org/10.1038/nchembio.1614
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DOI: https://doi.org/10.1038/nchembio.1614
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