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DNA metabolism

Bases of DNA repair and regulation

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An Erratum to this article was published on 13 November 2014

Recent studies have identified the existence of modified cytosine bases in DNA that result from ten eleven translocation (Tet)-mediated oxidation of 5-methylcytosine. The demonstration that Tet oxidizes thymine to 5-hydroxymethyluracil has implications for our current view of DNA metabolism.

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Figure 1: 5hmU in genomic DNA is the result of Tet-induced oxidation or ROS exposure.

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Correspondence to Arne Klungland.

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Robertson, A., Dahl, J. & Klungland, A. Bases of DNA repair and regulation. Nat Chem Biol 10, 487–488 (2014). https://doi.org/10.1038/nchembio.1553

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