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Metabolism

Digging up enzyme functions

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Advances in genome sequencing and structural biology mean that we are now buried under an avalanche of predicted domains and structures of proteins with unknown functions. Two groups have used different methods to unearth the functions of previously cryptic bacterial enzymes, illuminating new reactions and metabolic pathways.

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Figure 1: Discovery of missing enzymes and new metabolic pathways.

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  1. Matthew J. Wargo is at the Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, Vermont, USA.,

    Matthew J Wargo

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  1. Matthew J Wargo
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Correspondence to Matthew J Wargo.

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The author declares no competing financial interests.

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Wargo, M. Digging up enzyme functions. Nat Chem Biol 10, 4–5 (2014). https://doi.org/10.1038/nchembio.1413

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