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Drug discovery

Rethinking cellular drug response

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Large-scale cell line profiling of drugs provides dose-response curves that contain numerous lesser-considered parameters. Understanding the reasons for systematic variation in these parameters offers new ways to compare drugs and potentially to guide improved drug profiles.

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Figure 1: A model for how fractional cell killing may relate to dose-response curve steepness.

Marina Corral Spence

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Authors and Affiliations

  1. Jeremy L. Jenkins is in the Department of Developmental and Molecular Pathways at the Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.,

    Jeremy L Jenkins

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  1. Jeremy L Jenkins
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Correspondence to Jeremy L Jenkins.

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The author declares no competing financial interests.

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Jenkins, J. Rethinking cellular drug response. Nat Chem Biol 9, 669–670 (2013). https://doi.org/10.1038/nchembio.1365

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  • DOI: https://doi.org/10.1038/nchembio.1365

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