Vitamin B12–dependent radical enzymes that can undergo irreversible inactivation during catalysis have their own chaperones for the maintenance of catalytic activities. New research defines a mobile loop in the G protein that determines chaperone function and defines a switch III motif akin to that found in classical G proteins.
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Toraya, T. A switch saves B12 radical status. Nat Chem Biol 9, 530–531 (2013). https://doi.org/10.1038/nchembio.1314
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DOI: https://doi.org/10.1038/nchembio.1314
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