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Post-translational modifications

Panning for phosphohistidine

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Elusive pan-phosphohistidine (pHis) antibodies have been generated using a hydrolytically stable triazolyl-phosphonate hapten, promising to substantially accelerate efforts to better understand the role of pHis in biology.

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Figure 1: Panning for phosphohistidine just got much easier.

Katie Vicari

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Authors and Affiliations

  1. Matthew J. Piggott and Paul V. Attwood are at the School of Chemistry and Biochemistry, The University of Western Australia, Perth, Australia.,

    Matthew J Piggott & Paul V Attwood

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  1. Matthew J Piggott
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  2. Paul V Attwood
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Correspondence to Matthew J Piggott or Paul V Attwood.

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The authors declare no competing financial interests.

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Piggott, M., Attwood, P. Panning for phosphohistidine. Nat Chem Biol 9, 411–412 (2013). https://doi.org/10.1038/nchembio.1273

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