Post-translational modification of proteins by N-acetylglucosamine (O-GlcNAc) is carried out by a single glycosyltransferase, OGT. Two independent groups have generated structures of ternary complexes that elegantly illuminate substrate and product binding modes, and thus the overall reaction coordinate, but the respective authors differ in their choice of catalytic base.
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13 November 2012
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Withers, S., Davies, G. The case of the missing base. Nat Chem Biol 8, 952–953 (2012). https://doi.org/10.1038/nchembio.1117
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DOI: https://doi.org/10.1038/nchembio.1117
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