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Lipids

Tafazzin senses curvature

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The phospholipid-lysophospholipid transacylase tafazzin is responsible for enrichment of the cardiolipin fraction of mitochondria with tetralinoleoyl-cardiolipin. The specificity for linoleoyl hydrocarbon chains is now explained by the specific action of tafazzin on negatively curved lipid monolayers.

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Figure 1: Schematic presentation of a mitochondrion.

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Authors and Affiliations

  1. Klaus Gawrisch is at the Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland, USA.,

    Klaus Gawrisch

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  1. Klaus Gawrisch
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Correspondence to Klaus Gawrisch.

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Gawrisch, K. Tafazzin senses curvature. Nat Chem Biol 8, 811–812 (2012). https://doi.org/10.1038/nchembio.1068

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