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Peroxidasin

Tying the collagen-sulfilimine knot

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Type IV collagen, a major constituent of basement membranes, contains an unusual intermolecular sulfilimine crosslink whose route of biosynthesis has remained undefined. An oxidative triad consisting of peroxidasin, H2O2 and halide is now shown to drive sulfilimine generation in vivo.

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Figure 1: Peroxidasin-mediated formation of the NC1 sulfilimine knot.

Marina Corral

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Authors and Affiliations

  1. Stephen J. Weiss is in the Division of Molecular Medicine and Genetics, the Department of Internal Medicine and the Life Sciences Institute at the University of Michigan, Ann Arbor, Michigan, USA,

    Stephen J Weiss

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  1. Stephen J Weiss
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Correspondence to Stephen J Weiss.

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Weiss, S. Tying the collagen-sulfilimine knot. Nat Chem Biol 8, 740–741 (2012). https://doi.org/10.1038/nchembio.1050

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