Skip to main content
SpringerLink
Log in

Membranes

First steps to rafts?

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

Single-molecule observations reveal that lipid- and protein-based interactions jointly contribute to the interactions among glycosylphosphatidylinositol-anchored proteins in membranes. Understanding these interactions will help to refine long-evolving (and still debated) models of 'raft' domains in biological membranes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Cholesterol and the phosphatidylinositol-glycan anchor stabilize interactions between GPI-proteins in membranes.

References

  1. Simons, K. & Ikonen, I. Nature 387, 569–572 (1997).

    Article  CAS  Google Scholar 

  2. Munro, S. Cell 115, 377–388 (2003).

    Article  CAS  Google Scholar 

  3. Suzuki, K.G.N. et al. Nat. Chem. Biol. 8, 774–783 (2012).

    Article  CAS  Google Scholar 

  4. Hancock, J.F. Nat. Rev. Mol. Cell Biol. 7, 456–462 (2006).

    Article  CAS  Google Scholar 

  5. Simons, K. & Gerl, M.J. Nat. Rev. Mol. Cell Biol. 11, 688–699 (2010).

    Article  CAS  Google Scholar 

  6. Douglass, A.D. & Vale, R.D. Cell 121, 937–950 (2005).

    Article  CAS  Google Scholar 

  7. Sharma, P. et al. Cell 116, 577–589 (2004).

    Article  CAS  Google Scholar 

  8. Gowrishankar, K. et al. Cell 149, 1353–1367 (2012).

    Article  CAS  Google Scholar 

  9. Chen, Y. et al. J. Cell Sci. 122, 3966–3972 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. John R. Silvius is in the Department of Chemistry, McGill University, Montreal, Quebec, Canada,

    John R Silvius

Authors
  1. John R Silvius
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to John R Silvius.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Silvius, J. First steps to rafts?. Nat Chem Biol 8, 743–744 (2012). https://doi.org/10.1038/nchembio.1045

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.1045

  • Springer Nature America, Inc.

Search

Navigation