The dynamics of a complex chemical reaction that occurs through a well-defined intermediate have been followed at the single-molecule level using a 'nanoreactor' set-up, revealing a primary hydrogen isotope effect that is invisible to ensemble experiments.
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Garcia-Manyes, S. Caught in the act. Nature Chem 2, 905–906 (2010). https://doi.org/10.1038/nchem.882
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DOI: https://doi.org/10.1038/nchem.882
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