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Protein–protein interactions

Making drug design second nature

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Identifying inhibitors of protein–protein interactions is an ongoing challenge in the field of drug design, but the use of peptide fragments based on a known binding interface is showing promise.

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Figure 1: Drug-binding sites and tubulin–tubulin contact regions.

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Authors and Affiliations

  1. Dan Sackett is in the Laboratory of Integrative and Medical Biophysics, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 9 Memorial Drive, Bethesda Maryland 20892-0924, USA. sackettd@mail.nih.gov,

    Dan L. Sackett

  2. David Sept is in the Department of Biomedical Engineering and the Center for Computational Medicine and Bioinformatics at the University of Michigan, 1101 Beal Ave, Ann Arbor, Michigan 4810, USA. dsept@umich.edu,

    David Sept

Authors
  1. Dan L. Sackett
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  2. David Sept
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Sackett, D., Sept, D. Making drug design second nature. Nature Chem 1, 596–597 (2009). https://doi.org/10.1038/nchem.427

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