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Cytosolic delivery

Just passing through

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Intracellular protein delivery has been a major challenge in the field of cell biology for decades. Engineering such delivery is a key step in the development of protein- and antibody-based therapeutics. Now, two different approaches that enable the delivery of antibodies and antibody fragments into the cytosol have been developed.

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Figure 1: Achieving cytosolic protein delivery.

References

  1. Mitragotri, A., Burke, P. A. & Langer, R. Nat. Rev. Drug Discov. 13, 655–672 (2014).

    Article  CAS  Google Scholar 

  2. Oller-Salvia, B., Sánchez-Navarro, M., Giralt, E. & Teixidó, M. Chem. Soc. Rev. 45, 4690–4707 (2016).

    Article  CAS  Google Scholar 

  3. Singh, R., Singh, S. & Lillard, J. W. Jr J. Pharm. Sci. 97, 2497–2523 (2008).

    Article  CAS  Google Scholar 

  4. Schwarze, S. R., Ho, A., Vocero-Akbani, A. & Dowdy, S. F. Science 285, 1569–72 (1999).

    Article  CAS  Google Scholar 

  5. Derossi, D., Chassaing, G., Prochiantz, A. et al. Trends Cell Biol. 8, 84–87 (1998).

    Article  CAS  Google Scholar 

  6. Virès, E., Granier, C., Prevot, P. & Lebleu, B. Lett. Pept. Sci. 4, 429–436 (1997).

    Article  Google Scholar 

  7. Lundberg, M. & Johansson, M. Biochem. Biophys. J. 29, 367–371 (2002).

    Google Scholar 

  8. Akishiba, M. et al. Nat. Chem. 9, 751–761 (2017).

    Article  CAS  Google Scholar 

  9. Herce, H. D. et al. Nat. Chem. 9, 762–771 (2017).

    Article  CAS  Google Scholar 

  10. Lättig-Tünnemann, G. et al. Nat. Commun. 2, 453 (2011).

    Article  Google Scholar 

  11. Sánchez-Navarro, M., Garcia, J, Giralt, E. & Teixidó, M. Adv. Drug Delivery Rev. 106, 355–366 (2016).

    Article  Google Scholar 

  12. Rothbauser, U. et al. Nat. Struct. Mol. Biol. 17, 133–138 (2009).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Macarena Sánchez-Navarro, Meritxell Teixidó and Ernest Giralt are at the Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain,

    Macarena Sánchez-Navarro, Meritxell Teixidó & Ernest Giralt

  2. E. G. is also at the Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain,

    Ernest Giralt

Authors
  1. Macarena Sánchez-Navarro
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  2. Meritxell Teixidó
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  3. Ernest Giralt
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Correspondence to Ernest Giralt.

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Sánchez-Navarro, M., Teixidó, M. & Giralt, E. Just passing through. Nature Chem 9, 727–728 (2017). https://doi.org/10.1038/nchem.2837

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