Free radicals are notorious for unselective coupling reactions; however, the coupling of free radicals generated from acyl tellurides has now been shown to form C–C bonds with remarkable fidelity, which enables easy one-step assembly of densely oxygenated natural product motifs.
References
Qin, T. et al. Science 352, 801–805 (2016).
Giese, B. et al. Liebigs Ann. Chem. 1988, 997–1000 (1988).
Depew, K. M. et al. J. Am. Chem. Soc. 121, 11953–11963 (1999).
Schäfer, H.-J. Top. Curr. Chem. 152, 91–151 (1990).
Yamada, Y. & Momose, D.-i. Chem. Lett. 10, 1277–1278 (1981).
Movassaghi, M. & Schmidt, M. Angew. Chem. Int. Ed. 46, 3725–3728 (2007).
Fürstner, A. & Bogdanović, B. Angew. Chem. Int. Ed. 35, 2442–2469 (1996).
Nicolaou, K. C. et al. Angew. Chem. Int. Ed. 48, 7140–7165 (2009).
Nagatomo, M. et al. Angew. Chem. Int. Ed. 54, 1537–1541 (2015).
Nagatomo, M. et al. Chem. Sci. 6, 2765–2769 (2015).
Matsumura, S. et al. Tetrahedron 72, 4859–4866 (2016).
Masuda, K., Nagatomo, M. & Inoue, M. Nat. Chem. 9, 207–212 (2017).
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Zhang, W., Li, A. A radical step forward. Nature Chem 9, 198–199 (2017). https://doi.org/10.1038/nchem.2734
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DOI: https://doi.org/10.1038/nchem.2734
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