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Bioanalytical chemistry

Protein oligomers frozen in time

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The size and shape of amyloid-β protein assemblies have been studied using electrospray-ionization ion-mobility mass spectrometry, and the protein tetramers and dodecamers have been identified as an important oligomerization state in the development of neurodegenerative disease.

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Figure 1: Electrospray ionization allows protein oligomers in solution to be frozen out and their size and shape to be determined by ion-mobility spectrometry.

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Authors and Affiliations

  1. David E. Clemmer and Stephen J. Valentine are in the Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA. clemmer@indiana.edu,

    David E. Clemmer & Stephen J. Valentine

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  1. David E. Clemmer
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  2. Stephen J. Valentine
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Clemmer, D., Valentine, S. Protein oligomers frozen in time. Nature Chem 1, 257–258 (2009). https://doi.org/10.1038/nchem.264

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