'Click' chemistry allows for the linking together of chemical modules, however, there are currently no methods that also allow for facile 'declicking' to unlink them. Now, a method has been developed to click together amines and thiols, and then allow a chemically triggered declick reaction to release the original molecular components.
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Fulton, D. Click chemistry gets reversible. Nature Chem 8, 899–900 (2016). https://doi.org/10.1038/nchem.2626
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DOI: https://doi.org/10.1038/nchem.2626
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