A new click-style reaction based on a strain-release amination strategy has been developed. This approach can be used to append small, strained ring systems onto a core scaffold.
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Kolb, H. C., Finn, M. G. & Sharpless, K. B. Angew. Chem. Int. Ed. 40, 2004–2021 (2001).
Wiberg, K. B. Angew. Chem. Int. Ed. Engl. 25, 312–322 (1986).
De Meijere, A., Kozhushkov, S. I. & Schill, H. Chem. Rev. 106, 4926–4996 (2006).
Gianatassio, R. et al. Science 351, 241–246 (2016).
Schreiber, S. L. Science 287, 1964–1969 (2000).
Walczak, M. A. A., Krainz, T. & Wipf, P. Acc. Chem. Res. 48, 1149–1158 (2015).
Yu, L., Liu, M., Chen, F. & Xu, Q. Org. Biomol. Chem. 13, 8379–8392 (2015).
Petronijevic, F. R. & Wipf, P. J. Am. Chem. Soc. 133, 7704–7707 (2011).
Chen, K., Sun, R., Wei, Y. & Shi, M. Org. Biomol. Chem. 11, 3949–3953 (2013).
Brown, D. et al. J. Chem. Soc. Perkin Trans. 1 2014–2021 (2002).
Nicolaou, K. C. et al. J. Am. Chem. Soc. 138, 1698–1708 (2016).
Lovering, F., Bikker, J. & Humblet, C. J. Med. Chem. 52, 6752–6756 (2009).
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Milligan, J., Wipf, P. Straining to react. Nature Chem 8, 296–297 (2016). https://doi.org/10.1038/nchem.2485
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DOI: https://doi.org/10.1038/nchem.2485
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