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Deadly DNA

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DNA self-assembly has previously been used to create channel-like structures that can penetrate through lipid bilayer membranes. However, such assemblies have not been shown to cause cell death before. Now a DNA nanopore has been shown to exert a cytotoxic effect when administered to cells.

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Figure 1: Assembly of DNA nanotubes into a channel-like structure that spans the cell membrane can lead to cell death.

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Authors and Affiliations

  1. Swati Krishnan and Friedrich C. Simmel are in the Department of Physics, Technical University Munich, 85748 Garching, Munich, Germany,

    Swati Krishnan & Friedrich C. Simmel

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  1. Swati Krishnan
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  2. Friedrich C. Simmel
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Correspondence to Friedrich C. Simmel.

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Krishnan, S., Simmel, F. Deadly DNA. Nature Chem 7, 17–18 (2015). https://doi.org/10.1038/nchem.2148

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