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The I's have it

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Rotaxanes with cyclodextrin end groups have been used as a platform to investigate anion binding in water, revealing that halogen bonding can serve as the basis for molecular recognition in aqueous solvents, which may have implications in medicinal chemistry and beyond.

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Figure 1: General depiction of a halogen bonding interaction (top), the structure of a bis(iodotriazole) halogen-bond donor (middle), and an electrostatic potential map (bottom) showing the 'σ-hole' (blue region of partial positive potential) on each iodine atom.
Figure 2: Rotaxanes and their anion-binding properties.

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  1. Mark S. Taylor is in the Department of Chemistry, University of Toronto, Ontario M5S 3H6, Canada,

    Mark S. Taylor

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  1. Mark S. Taylor
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Correspondence to Mark S. Taylor.

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Taylor, M. The I's have it. Nature Chem 6, 1029–1031 (2014). https://doi.org/10.1038/nchem.2121

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