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Drug discovery

Combichem all over again

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The generation of chemical libraries for screening is a key part of the drug discovery process. Now, two studies describe attempts to combine features of natural product biosynthesis into the creation of libraries with the aim of mimicking nature's success at the production of bioactive molecules.

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Figure 1: Contemporary approaches to combinatorial chemistry.

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Authors and Affiliations

  1. Derek Lowe is at Vertex Pharmaceuticals 50 Northern Avenue, Boston, Massachussets 02210, USA,

    Derek B. Lowe

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  1. Derek B. Lowe
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Correspondence to Derek B. Lowe.

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Lowe, D. Combichem all over again. Nature Chem 6, 851–852 (2014). https://doi.org/10.1038/nchem.2074

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