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Enzyme mechanisms

Flexibility leads to function

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ATP synthase is an important enzyme for the storage and release of energy in cells. Ion-mobility mass spectrometry has now been used to study its structure, revealing important mechanistic details about its operation and regulation.

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Figure 1: Assembly and operation of the V/A-type ATP synthase from T. thermophilus.

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Authors and Affiliations

  1. Jianhua Zhao and John Rubinstein are in the Department of Medical Biophysics at the University of Toronto, 610 University Ave., Toronto, Ontario, M5G 2M9, Canada and at The Hospital for Sick Children Research Institute, 686 Bay Street, Room 20-9400T, Toronto, Ontario, M5G 0A4, Canada,

    Jianhua Zhao & John L. Rubinstein

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  1. Jianhua Zhao
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  2. John L. Rubinstein
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Correspondence to John L. Rubinstein.

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Zhao, J., Rubinstein, J. Flexibility leads to function. Nature Chem 6, 170–171 (2014). https://doi.org/10.1038/nchem.1879

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