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Heparin sensing

Blue-chip binding

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Heparin is an anionic polysaccharide that has tremendous clinical importance as an anticoagulant. Several dyes have been developed that can detect heparin, and the latest example — named Mallard Blue — has now been shown to have excellent sensing properties under biologically relevant conditions.

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Figure 1: Molecular make-up of the complex polysaccharides heparin and heparan sulfate, and the structures of heparin-binding dyes.

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Acknowledgements

R.S. would like to acknowledge support from National Institutes of Health (R37 GM057073-13).

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Authors and Affiliations

  1. Department of Biological Engineering, Zachary Shriver and Ram Sasisekharan are at the Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA,

    Zachary Shriver & Ram Sasisekharan

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  1. Zachary Shriver
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  2. Ram Sasisekharan
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Correspondence to Ram Sasisekharan.

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Shriver, Z., Sasisekharan, R. Blue-chip binding. Nature Chem 5, 644–646 (2013). https://doi.org/10.1038/nchem.1701

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