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Enzyme mimics

Halogen and chalcogen team up

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The behaviour of di-selenol enzyme mimics indicates that a halogen bond between selenium and iodine, and a chalcogen interaction between the two selenium atoms, play an important role in the activation of thyroid hormones.

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Figure 1: The peri-substituted naphthalene-diselenol 1 efficiently removes iodine (shown in purple) from the inner ring of thyroxine (3,5,3′,5′-tetraiodothyronine, T4), yielding 3,3′,5′-triiodothyronine (rT3) (top).

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Authors and Affiliations

  1. Pierangelo Metrangolo and Giuseppe Resnati are in the Department of Chemistry, Materials, and Chemical Engineering “Giulio Natta”, and at the Center for Nano Science and Technology of the Italian Institute of Technology, both at the Politecnico di Milano, Milano, 20133, Italy,

    Pierangelo Metrangolo & Giuseppe Resnati

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  1. Pierangelo Metrangolo
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  2. Giuseppe Resnati
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Correspondence to Pierangelo Metrangolo or Giuseppe Resnati.

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Metrangolo, P., Resnati, G. Halogen and chalcogen team up. Nature Chem 4, 437–438 (2012). https://doi.org/10.1038/nchem.1355

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