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Welwitindolinone is well worth it

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Recent syntheses of the natural product 3-hydroxy-N-methylwelwitindolinone C isothiocyanate are taken as examples to answer an oft-raised question about the value of total synthesis.

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Figure 1
Figure 2: Competing synthetic routes to 3-hydroxy-N-methylwelwitindolinone C isothiocyanate.

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Authors and Affiliations

  1. John L. Wood is the A. I. Meyers Professor of Chemistry in the Chemistry Department at Colorado State University, Fort Collins, Colorado 80523, USA,

    John L. Wood

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  1. John L. Wood
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Correspondence to John L. Wood.

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Wood, J. Welwitindolinone is well worth it. Nature Chem 4, 341–343 (2012). https://doi.org/10.1038/nchem.1335

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