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Nucleic acid hybridization

Robust sequence discrimination

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Careful consideration of thermodynamics has allowed the design of nucleic acid probes that are highly specific and virtually unaffected by changes in reaction conditions.

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Figure 1: Toehold exchange hybridization.

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Authors and Affiliations

  1. Grégoire Altan-Bonnet is in the Computational Biology Program at the Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA,

    Grégoire Altan-Bonnet

  2. Fred Russell Kramer is at the New Jersey Medical School, Public Health Research Institute, 225 Warren Street, Newark, New Jersey 07103, USA,

    Fred Russell Kramer

Authors
  1. Grégoire Altan-Bonnet
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  2. Fred Russell Kramer
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Correspondence to Grégoire Altan-Bonnet or Fred Russell Kramer.

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Altan-Bonnet, G., Kramer, F. Robust sequence discrimination. Nature Chem 4, 155–157 (2012). https://doi.org/10.1038/nchem.1283

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