A new type of protein–polymer conjugate provides improved stability without detrimentally affecting bioactivity, and thus offers great potential for the development of new peptide-based drugs.
This is a preview of subscription content, log in via an institution to check access.
ENZYME: ©ISTOCKPHOTO.COM/MARTIN MCCARTHY
References
Leader, B., Baca, Q. J. & Golan, D. E. Nature Rev. Drug Discov. 7, 21–39 (2008).
Wild, S., Roglic, G., Green, A., Sicree, R. & King, H. Diabetes Care 27, 1047–1053 (2004).
Veronese, F. M. & Pasut, G. Drug Discov. Today 10, 1451–1458 (2005).
Veronese, F. M & Mero, A. Biodrugs 22, 315–329 (2008).
Bailon, P. et al. Bioconjugate Chem. 12, 195–202 (2001).
Keefe, A. J. & Jiang, S. Nature Chem. 4, 59–63 (2012).
Yang, W., Zhang, L., Wang, S., White, A. D. & Jiang, S. Biomaterials 30, 5617–5621 (2009).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Parrott, M., DeSimone, J. Relieving PEGylation. Nature Chem 4, 13–14 (2012). https://doi.org/10.1038/nchem.1230
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchem.1230
- Springer Nature Limited
This article is cited by
-
Applying an innovative biodegradable self-assembly nanomicelles to deliver α-mangostin for improving anti-melanoma activity
Cell Death & Disease (2019)
-
Priming the body to receive the therapeutic agent to redefine treatment benefit/risk profile
Scientific Reports (2018)
-
Chitosan Nanolayered Cisplatin-Loaded Lipid Nanoparticles for Enhanced Anticancer Efficacy in Cervical Cancer
Nanoscale Research Letters (2016)
-
Orthogonal analysis of functional gold nanoparticles for biomedical applications
Analytical and Bioanalytical Chemistry (2015)