Skip to main content
SpringerLink
Log in

RNA structure

Adding a second dimension

  • News & Views
  • Published:

From Nature Chemistry

View current issue Submit your manuscript

Mutating RNA one nucleotide at a time and measuring the impact of this on its chemical reactivity provides a strategy for determining its three-dimensional structure, and from there, hopefully, its function.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: From chemical mapping to 3D structure.

References

  1. Weeks, K. M. & Mauger, D. M. Acc. Chem. Res. http://dx.doi.org/10.1021/ar200051h (2011).

  2. Kladwang, W., VanLang, C. C., Cordero, P. & Das, R. Nature Chem. 3, 954–962 (2011).

    Article  CAS  Google Scholar 

  3. Aue, W. P., Bartholdi, E. & Ernst, R. R. J. Chem. Phys. 64, 2229–2246 (1976).

    Article  CAS  Google Scholar 

  4. Wüthrich, K. NMR of Proteins and Nucleic Acids Vol. 1 (Wiley-VCH, 1986).

    Book  Google Scholar 

  5. Kladwang, W., Vanlang, C. C., Cordero, P. & Das, R. Biochemistry 50, 8049–8056 (2011).

    Article  CAS  Google Scholar 

  6. Das, R., Karanicolas, J. & Baker, D. Nature Methods 7, 291–294 (2010).

    Article  CAS  Google Scholar 

  7. Kladwang, W., Cordero, P. & Das, R. RNA 17, 522–534 (2011).

    Article  CAS  Google Scholar 

  8. Al-Hashimi, H. M. & Walter, N. G. Curr. Opin. Struct. Biol. 18, 321–329 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Katja Petzold and Hashim M. Al-Hashimi are in the Department of Chemistry and Biophysics at the University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA,

    Katja Petzold & Hashim M. Al-Hashimi

Authors
  1. Katja Petzold
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hashim M. Al-Hashimi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hashim M. Al-Hashimi.

Ethics declarations

Competing interests

H.M.A.-H. is an advisor to and holds an ownership interest in Nymirum, an RNA-based drug-discovery company.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Petzold, K., Al-Hashimi, H. Adding a second dimension. Nature Chem 3, 913–915 (2011). https://doi.org/10.1038/nchem.1209

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchem.1209

  • Springer Nature Limited

This article is cited by

Search

Navigation