The synthesis and biological investigation of a family of natural products and unnatural analogues illustrates the importance of considering both form and function in the planning of any synthesis.
References
Baran, P. S. & Maimone, T. J. Nature Chem. Biol. 3, 396–407 (2007).
Holton, R. A. et al. J. Am. Chem. Soc. 116, 1599–1600 (1994).
Nicolaou, K. C. et al. Nature 367, 630–634 (1994).
Masters, J. J. et al. Angew. Chem. Int. Ed. Engl. 34, 1723–1726 (1995).
Wender, P. A. et al. J. Am. Chem. Soc. 119, 2755–2756 (1997).
Mukaiyama, T. et al. Proc. Jpn. Acad. Ser. B 73, 95–100 (1997).
Morihira, K. et al. J. Am. Chem. Soc. 120, 12980–12981 (1998).
Doi, T. et al. Chem. Asian J. 1, 370–383 (2006).
Ishihara, Y. & Baran, P. S. Synlett 1733–1745 (2010).
Wender, P. A. et al. Nature Chem. 3, 615–619 10.1038/nchem.1074 (2011).
Wender, P. A. et al. J. Am. Chem. Soc. 119, 12976–12977 (1997).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Phillips, A. Function first. Nature Chem 3, 575–576 (2011). https://doi.org/10.1038/nchem.1105
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchem.1105
- Springer Nature Limited