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MK2 balances inflammation and cell death

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The cytokine tumour necrosis factor (TNF) and the toll-like receptors (TLRs) coordinate immune responses by activating inflammatory transcriptional programs, but these signals can also trigger cell death. Recent studies identify the MAP kinase substrate MK2 as a key player in determining whether cells live or die in response to TNF and TLR signalling.

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Figure 1: MK2 checks RIPK1-dependent cell death.

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Authors and Affiliations

  1. Department of Immunology, University of Washington, Seattle, 98109, Washington, USA

    Andrew Oberst

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  1. Andrew Oberst
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Correspondence to Andrew Oberst.

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Oberst, A. MK2 balances inflammation and cell death. Nat Cell Biol 19, 1150–1152 (2017). https://doi.org/10.1038/ncb3619

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