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Myofibrils put the squeeze on nuclei

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During muscle development, nuclei travel from the centre of the myofibre to the periphery, a process defective in certain diseases. A new study reveals that this movement is due to centripetal forces imposed on nuclei by the crosslinking and contraction of myofibrils.

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Figure 1: Myonuclear movement during muscle development.
Figure 2: Myofibril zipping causes myonuclear extrusion to the periphery.

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Acknowledgements

J.N.R. and M.K.B. are supported by the NIH (GM078318, AR108981) to M.K.B. and National Cancer Institute (P30 CA 008748) core grant to Memorial Sloan Kettering Cancer Center.

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Authors and Affiliations

  1. Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, 10065, New York, USA

    Jonathan N. Rosen & Mary K. Baylies

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  1. Jonathan N. Rosen
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  2. Mary K. Baylies
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Correspondence to Mary K. Baylies.

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The authors declare no competing financial interests.

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Rosen, J., Baylies, M. Myofibrils put the squeeze on nuclei. Nat Cell Biol 19, 1148–1150 (2017). https://doi.org/10.1038/ncb3618

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