Obesity now rivals smoking as one of the leading preventable causes of cancer. Obesity-associated neutrophilia is now shown to enhance breast cancer metastasis and to be reversible through dietary modification and weight loss.
References
Calle, E. E. & Kaaks, R. Nat. Rev. Cancer 4, 579–591 (2004).
Ligibel, J. A. et al. J. Clin. Oncol. 32, 3568–3574 (2014).
Coussens, L. M., Zitvogel, L. & Palucka, A. K. Science 339, 286–291 (2013).
McAllister, S. S. & Weinberg, R. A. Nat. Cell Biol. 16, 717–727 (2014).
Peinado, H. et al. Nat. Rev. Cancer 17, 302–317 (2017).
Quail, D. F. et al. Nat. Cell Biol. 19, 974–987 (2017).
Osman, M. A. & Hennessy, B. T. Clin. Med. Insights Oncol. 9, 105–112 (2015).
Weigelt, B., Peterse, J. L. & van 't Veer, L. J. B Nat. Rev. Cancer 5, 591–602 (2005).
Zhang, Y. et al. Nature 372, 425–432 (1994).
Alemán, J. O. et al. J. Endocr. Soc. 1, 625–637 (2017).
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Sceneay, J., McAllister, S. The skinny on obesity and cancer. Nat Cell Biol 19, 887–888 (2017). https://doi.org/10.1038/ncb3583
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DOI: https://doi.org/10.1038/ncb3583
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