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Revolving around constriction by ESCRT-III

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The endosomal sorting complex required for transport (ESCRT)-III is critical for membrane abscission; however, the mechanism underlying ESCRT-III-mediated membrane constriction remains elusive. A study of the dynamic assembly and disassembly of the ESCRT-III machinery in vitro and in vivo now suggests that the turnover of the observed spiralling filaments is critical for membrane abscission during cytokinesis.

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Figure 1: Dynamic ESCRT-III and revolving FtsZ ring-like filaments caused by subunit turnover.

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Authors and Affiliations

  1. Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany

    Henri G. Franquelim & Petra Schwille

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  1. Henri G. Franquelim
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  2. Petra Schwille
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Correspondence to Petra Schwille.

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The authors declare no competing financial interests.

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Franquelim, H., Schwille, P. Revolving around constriction by ESCRT-III. Nat Cell Biol 19, 754–756 (2017). https://doi.org/10.1038/ncb3569

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