Epithelial cells form energetically costly cell–cell adhesions in response to mechanical forces. How cells obtain their energy during this event is unclear. Activity of a key regulator of cell metabolism, the AMP-activated protein kinase (AMPK), is now shown to be mechanoresponsive, and thus can bridge adhesion mechanotransduction and energy homeostasis.
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Isogai, T., Park, J. & Danuser, G. Cell forces meet cell metabolism. Nat Cell Biol 19, 591–593 (2017). https://doi.org/10.1038/ncb3542
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DOI: https://doi.org/10.1038/ncb3542
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