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Twist of fate for skeletal muscle mesenchymal cells

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Skeletal muscles are composed of different types of fibres. Can these be thought of as distinct lineages with specific lineage-restricted progenitors? A provocative study now proposes that mesenchymal cells expressing the transcription factor Twist2 act as myogenic progenitors with selective type IIb fibre-differentiation potential.

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Figure 1: Fibre-type-specific contribution of Twist2+ cells.

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Authors and Affiliations

  1. and Department of Pediatrics, Natalya A. Goloviznina and Michael Kyba are at the Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA,

    Natalya A. Goloviznina & Michael Kyba

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  1. Natalya A. Goloviznina
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  2. Michael Kyba
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Correspondence to Michael Kyba.

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The authors declare no competing financial interests.

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Goloviznina, N., Kyba, M. Twist of fate for skeletal muscle mesenchymal cells. Nat Cell Biol 19, 153–154 (2017). https://doi.org/10.1038/ncb3482

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