Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process, including a role for non-homologous end joining.
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Hatch, E. Y chromothripsis?. Nat Cell Biol 19, 12–14 (2017). https://doi.org/10.1038/ncb3458
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DOI: https://doi.org/10.1038/ncb3458
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