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Resolving the cadherin–F-actin connection

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Cadherin adhesion complexes have recently emerged as sensors of tissue tension that regulate key developmental processes. Super-resolution microscopy experiments now unravel the spatial organization of the interface between cadherins and the actin cytoskeleton and reveal how vinculin, a central component in cadherin mechanotransduction, is regulated by mechanical and biochemical signals.

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Figure 1: Mechanochemical regulation of vinculin within the cadherin/F-actin interface.

References

  1. Munjal, A. & Lecuit, T. Development 141, 1789–1793 (2014).

    Article  CAS  Google Scholar 

  2. Twiss, F. & de Rooij, J. Cell Mol. Life Sci. 70, 4101–4116 (2013).

    Article  CAS  Google Scholar 

  3. Bertocchi, C. et al. Nat. Cell Biol. 19, 28–37 (2017).

    Article  CAS  Google Scholar 

  4. Han, M. K. L. & de Rooij, J. Trends Cell Biol. 26, 612–623 (2016).

    Article  Google Scholar 

  5. Ladoux, B., Nelson, W. J., Yan, J. & Mège, R. M. Integr. Biol. 7, 1109–1119 (2015).

    Article  CAS  Google Scholar 

  6. Yonemura, S., Wada, Y., Watanabe, T., Nagafuchi, A. & Shibata, M. Nat. Cell Biol. 12, 533–542 (2010).

    Article  CAS  Google Scholar 

  7. Kanchanawong, P. et al. Nature 468, 580–584 (2010).

    Article  CAS  Google Scholar 

  8. Bays, J. L. et al. J. Cell Biol. 205, 251–263 (2014).

    Article  CAS  Google Scholar 

  9. Auernheimer, V. et al. J. Cell Sci. 128, 3435–3443 (2015).

    Article  CAS  Google Scholar 

  10. Atherton, P., Stutchbury, B., Jethwa, D. & Ballestrem, C. Exp. Cell Res. 343, 21–27 (2016).

    Article  CAS  Google Scholar 

  11. Pasapera, A. M., Schneider, I. C., Rericha, E., Schlaepfer, D. D. & Waterman, C. M. J. Cell Biol. 188, 877–890 (2010).

    Article  CAS  Google Scholar 

  12. Ladoux, B. et al. Biophys. J. 98, 534–542 (2010).

    Article  CAS  Google Scholar 

  13. Kris, A. S., Kamm, R. D. & Sieminski, A. L. Biochem. Biophys. Res. Commun. 375, 134–138 (2008).

    Article  CAS  Google Scholar 

  14. Leerberg, J. M. et al. Curr. Biol. 24, 1689–1699 (2014).

    Article  CAS  Google Scholar 

  15. Huveneers, S. et al. J. Cell Biol. 196, 641–652 (2012).

    Article  CAS  Google Scholar 

  16. Oldenburg, J. et al. Sci. Rep. 5, 17225 (2015).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Mitchell K. L. Han and Johan de Rooij are at the Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands,

    Mitchell K. L. Han & Johan de Rooij

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  1. Mitchell K. L. Han
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  2. Johan de Rooij
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Correspondence to Johan de Rooij.

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Han, M., de Rooij, J. Resolving the cadherin–F-actin connection. Nat Cell Biol 19, 14–16 (2017). https://doi.org/10.1038/ncb3457

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