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IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3

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Despite being one of the most studied signalling pathways, precisely how phospholipid synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The scaffold protein IQGAP1 is now shown to orchestrate the assembly of a multi-enzyme complex that streamlines PtdIns(3,4,5)P3 synthesis to facilitate Akt activation in response to extracellular stimuli.

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Figure 1: A diagram depicting two modalities of phosphoinositide signalling; a processive mode and a non-processive mode.

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Authors and Affiliations

  1. Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, 02118, Massachusetts, USA

    Lucia E. Rameh

  2. Department of Ophthalmology, Schepens Eye Research Institute/Mass Eye and Ear, Harvard Medical School, Boston, 02114, Massachusetts, USA

    Ashley M. Mackey

Authors
  1. Lucia E. Rameh
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  2. Ashley M. Mackey
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Correspondence to Lucia E. Rameh.

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The authors declare no competing financial interests.

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Rameh, L., Mackey, A. IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3. Nat Cell Biol 18, 1263–1265 (2016). https://doi.org/10.1038/ncb3440

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