Skip to main content
SpringerLink
Log in

On keeping the right ER size

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

The endoplasmic reticulum (ER) is the largest membrane-bound organelle in cells, and its size needs to be carefully controlled. Downsizing the ER by autophagy is now shown to involve Sec62, a protein that also helps to build up the organelle. This link suggests a molecular switch for ER size control.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Sec62 coordinates ER biogenesis and degradation.

References

  1. Haldane, J. B. S. On being the right size. Harper's Magazine (March, 1926); http://go.nature.com/2dvdGQL

  2. Federovitch, C. M., Ron, D. & Hampton, R. Y. Curr. Opin. Cell Biol. 17, 409–414 (2005).

    Article  CAS  Google Scholar 

  3. Fumagalli, F. et al. Nat. Cell Biol. 18, 1173–1184 (2016).

    Article  CAS  Google Scholar 

  4. Braakman, I. & Hebert, D. N. Cold Spring Harb. Perspect. Biol. 5, a013201 (2013).

    Article  Google Scholar 

  5. Walter, P. & Ron, D. Science 334, 1081–1086 (2011).

    Article  CAS  Google Scholar 

  6. Bolender, R. P. & Weibel, E. R. J. Cell Biol. 56, 746–761 (1973).

    Article  CAS  Google Scholar 

  7. Birgisdottir, A. B., Lamark, T. & Johansen, T. J. Cell Sci. 126, 3237–3247 (2013).

    CAS  Google Scholar 

  8. Wild, P., McEwan, D. G. & Dikic, I. J. Cell Sci. 127, 3–9 (2014).

    Article  CAS  Google Scholar 

  9. Rapoport, T. A. Nature 450, 663–669 (2007).

    Article  CAS  Google Scholar 

  10. Shibata, Y., Voeltz, G. K. & Rapoport, T. A. Cell 126, 435–439 (2006).

    Article  CAS  Google Scholar 

  11. Khaminets, A. et al. Nature 522, 354–358 (2015).

    Article  CAS  Google Scholar 

  12. Mochida, K. et al. Nature 522, 359–362 (2015).

    Article  CAS  Google Scholar 

  13. Schuck, S., Gallagher, C. M. A. & Walter, P. J. Cell Sci. 127, 4078–4088 (2014).

    Article  CAS  Google Scholar 

  14. Hetz, C., Chevet, E. & Harding, H. P. Nat. Rev. Drug Discov. 12, 703–719 (2013).

    Article  CAS  Google Scholar 

  15. Mizushima, N. & Komatsu, M. Cell 147, 728–741 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sebastian Schuck is at the CellNetworks Cluster of Excellence and Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Heidelberg University, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany,

    Sebastian Schuck

Authors
  1. Sebastian Schuck
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sebastian Schuck.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schuck, S. On keeping the right ER size. Nat Cell Biol 18, 1118–1119 (2016). https://doi.org/10.1038/ncb3430

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb3430

  • Springer Nature Limited

This article is cited by

Search

Navigation