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Hippo's Q for a big liver

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The Hippo pathway is a key regulator of organ size that has also been implicated in tumorigenesis. Yap, one of the effectors of Hippo signalling, is now reported to support these functions by promoting glutamine synthesis.

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Figure 1: Outline of the core Hippo pathway signalling components.

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Authors and Affiliations

  1. Dimitrios Anastasiou is at the Cancer Metabolism Laboratory, The Francis Crick Institute, The Ridgeway, London NW7 1AA, UK,

    Dimitrios Anastasiou

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  1. Dimitrios Anastasiou
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Correspondence to Dimitrios Anastasiou.

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Anastasiou, D. Hippo's Q for a big liver. Nat Cell Biol 18, 835–837 (2016). https://doi.org/10.1038/ncb3391

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